What Is Hyperbaric Oxygen Therapy (HBOT)?

August 14, 2025

Hyperbaric Oxygen Therapy (HBOT) involves breathing pure or enriched oxygen inside a pressurized chamber, typically at 1.3 to 2.4 times normal atmospheric pressure. This increased pressure allows oxygen to dissolve more efficiently into your plasma, reaching areas with poor circulation, tissue damage, or chronic inflammation.

Oxygen is fundamental to cellular energy production, tissue repair, and immune regulation. By increasing oxygen availability, HBOT activates the body’s natural healing mechanism.

How Does Hyperbaric Oxygen Therapy Work in the Body?

HBOT’s effects are deeply rooted in cellular biology and physiology:

1. Increased Oxygen Diffusion

Oxygen under pressure saturates your blood plasma and diffuses deep into tissues—even areas with reduced blood flow, accelerating healing and reducing hypoxia.

2. Stem Cell Mobilization

HBOT boosts the number of circulating stem cells by 2 to 8 times, enhancing tissue regeneration and repair capacity.

3. Angiogenesis (New Blood Vessel Formation

HBOT stimulates angiogenesis, supporting longer-term oxygen delivery by building new capillary networks in damaged or oxygen-deprived tissue.

4. Mitochondrial Function and Energy Production

Mitochondria are the cell’s energy generators, producing ATP. Dysfunctional mitochondria are linked to nearly all chronic diseases. HBOT supports mitochondrial repair and biogenesis, leading to:

  1. Improved energy levels
  2. Enhanced resilience
  3. Longevity at a cellular level

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What Are the Benefits of HBOT?

  • Neurological recovery: Stroke, traumatic brain injury, post-concussion syndrome, cerebral palsy
  • Chronic fatigue and fibromyalgia
  • Autoimmune diseases
  • Post-viral syndromes (including Long COVID)
  • Anti-aging and longevity session schedules
  • Sports performance and recovery
  • Pre- and post-surgical healing

The session schedule (pressure, frequency, and duration) depends on the condition and individual response. It’s not a one-size-fits-all therapy. HBOT session schedules should be tailored to the individuals’ health goals.

Is There Scientific Research Supporting HBOT?

Yes. HBOT is one of the most extensively researched interventions in regenerative and wound care medicine. Peer-reviewed studies have shown:

  • Neurological recovery: Stroke, traumatic brain injury, post-concussion syndrome, cerebral palsy
  • Chronic fatigue and fibromyalgia
  • Autoimmune diseases
  • Post-viral syndromes (including Long COVID)
  • Anti-aging and longevity session schedules
  • Sports performance and recovery
  • Pre- and post-surgical healing

Condition / Symptom

How HBOT May Help

Evidence Level

Chronic Wounds (e.g., diabetic foot)

Improves oxygenation in poorly perfused tissue, promotes healing

High

Post-Stroke Recovery

Enhances neuroplasticity and supports damaged brain tissue

Moderate

Radiation Tissue Damage

Stimulates angiogenesis and reduces fibrosis

High

Chronic Fatigue Syndrome

Supports mitochondrial function, boosts energy levels

Moderate

Traumatic Brain Injury (TBI)

Reduces inflammation, promotes neuroregeneration

Emerging

Sports Injury Recovery

Speeds up tissue repair and reduces downtime

Moderate